Abstract
There is clinical and experimental evidence that in biomedicine, the limit between what we consider normal and what we consider pathological is not always so clear and absolute. Conditions may arise in which, apparently without any explanation, one passes from one condition to another. A key role is played by changes that occur in the microenvironment surrounding a cell population. The terms normal and pathological have no absolute meaning on their own. They have their own meaning only if they are considered in the light of the relationships between the living being and its surrounding environment. Man is able to create new environments instead of passively enduring its changes. Any individual who deviates from a statistically defined normal individual will be considered pathological.
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