Abstract
This study displays a retrospective cohort analysis in the Reproductive and Genetic Health Center of Peking University First Hospital. Data were collected from 411 women receiving ART. The body composition, sex hormones and biochemical indicators were assessed by bioelectrical impedance analysis (BIA). Subjects were grouped by body mass index (BMI) and body fat percentage (BFP), and differences of body composition among groups were analyzed. Multiple linear regression analysis was used to evaluate the relationship between sex hormones, biochemical indicators and body composition. Compared with the non-overweight group (BMI < 24kg/m2), the lean body mass and fat mass of the overweight group (BMI≥24kg/m2) increased significantly (P < 0.001).
Highlights
The prevalence of obesity is increasing worldwide, almost tripling in the last four decades
In this study of women receiving Assisted Reproductive Techniques (ART), we found that with the elevation of body mass index (BMI), the lean body mass of Total Body Water (TBW), protein, bone mineral content (BMC) and muscle, fat mass of Trunk Fat Mass (TFM), Left Arm Fat Mass (LAFM), Left Leg Fat Mass (LLFM), Right Arm Fat Mass (RAFM), Right Leg Fat Mass (RLFM) and Visceral Adipose Tissue (VAT) increased
43.7% of subjects were considered as non-overweight, but as overweight when combined with Percentage of Body Fat (PBF) because of the increase in fat content, which indicated that BMI cannot distinguish between normal-weight people who maintained a large amount of fat and those who did not have excess fat
Summary
The prevalence of obesity is increasing worldwide, almost tripling in the last four decades. In 2016, over 650 million adults were obese, 15% of whom were women (WHO, 2017). More and more obese women are being evaluated for infertility [2]. Higher BMI was associated with worse ART outcomes, including lower implantation rates and increased risk of abortion [4,5,6,7]. Obesity is always characterized by a high BMI, which means changes in fat content, and other physical parameters, such as total body water (TBM), muscle and bone mineral content (BMC). For infertile women with the high BMI, more attention should be paid to the changes of body composition. It is necessary to explore the relationship between sexual hormones, metabolic markers and body composition
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