Abstract
Spasm and distention of smooth muscle in the walls of hollow viscera have been established as “adequate” stimuli for true visceral pain. The blood vessels exhibit these conditions in the same manner as the internal viscera and are provided with afferent pathways for the conduction of pain impulses. Experimental evidence is presented to demonstrate that pain may arise from abnormal degrees of spasm or distention of the walls of blood vessels. Instances are cited illustrating surgical sensitiveness of arteries and conditions giving rise to pain in veins. A number of clinical syndromes characterized by pain are mentioned, in which afferent impulses of pain may originate in the walls of blood vessels.
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