The Blood Sugar Content of the Cold=punctured (“Zwischenhirnstich” of E. Leschke) Rabbit

Abstract

1. In the “Zwischenhirnstich” of E. Leschke, the incision between the inter-and midbrain was a little enlarged. The fall of the body temperature of the cold-punctured rabbit is so remarkably rapid and great that results of Leschke and others who adopted Leschke's original method have no comparison. This procedure may be named as the “cold-puncture.” The reason is written in the text. The body temperature of my punctured rabbits falls to 33°C. in only about five hours; and finally it lowers to a little higher than the room temperature and varies with it. So, the result of the cold-puncture on the body temperature is quite the same as the extraction of the inter-brain of R. Isenschmid, while the process of cold-puncture is quite simple. 2. The blood sugar content of the cold-punctured rabbit, which recovers first to the normal value after the passing off of the operation hyperglycaemia, begins suddenly to increase as soon as the body temperature descends to about 30°C. and becomes greater, as the body temperature descends further. Glycosuria also occurs. (a) Failure of the cold puncture hyperglycaemia-glycosuria is due to the insufficiency of the liver glycogen content, except in a few cases. (b) The cold-puncture hyperglycaemia-glycosuria cannot be induced on the rabbit with bilateral splanchnectomy. So, it is one of central origin. The activity of the nervous mechanism of the sugar mobilization is intact on the cold-punctured rabbit.