Abstract
Prostaglandins were biosynthesized to test the hypothesis that essential fatty acids could act as precursors of prostaglandins (PGS). PGE2 the PGs with the greatest biological activity were addressed first. Because of the position of the double bonds and the fact that a bended conformation of arachidonic acid suggests the possibility of trans-annular reactions arachidonic acid was investigated for the biosynthesis of PGE2 and it was found that tritiated arachidonic acid is easily converted to PGE2 by a homogenate of vesicular glands of sheep via thin-layer chromatography. This conversion indicates that the function of essential fatty acids is to act as PG precursors.
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More From: Biochimica et Biophysica Acta (BBA) - General Subjects
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