Abstract
Swelling of the sex-skin was induced in five immature female rhesus monkeys by the administration of estrogen. The mucopolysaccharide content of this skin was compared with that of unswollen chest skin from the same animals and with untreated controls. The major difference was a 5-fold increase in the hyaluronic acid content of the sex skin. The biosynthetic rates of hyaluronic acid, dermatan sulfate, collagen, and non-collagen protein were studied by measuring the rate of incorporation of radioactively labeled precursors into these substances either in vivo or in vitro. A differential effect of the hormone was seen in that much more [ 14C]glucose was incorporated into hyaluronic acid and dermatan sulfate by sex skin than by non-sex skin. The incorporation of [ 3H]proline into collagen was also greater in the sex skin than in the non-sex skin. The rate of transfer of label from extractable toinsoluble collagen was, however, unaffected. Relatively little differential effect was seen in the incorporation of [ 3H]proline into non-collagen protein.
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