Abstract
The biosynthesis of prohormone-derived peptides is a complex cellular process, which requires specific cleavage, sorting, and modifications of the peptides before the final generation of the bioactive products. In this review, we describe the current knowledge of the cell biology of a key prohormone: proThyrotropin Releasing Hormone (proTRH), which is the precursor of the TRH peptide. In particular, we focus on the biosynthesis of the hypophysiotropic TRH, which is produced in the hypothalamic paraventricular nucleus (PVN) and is the main activator of the hypothalamic-pituitary-thyroid (HPT) axis. Recently, we showed that the regulation of the biosynthesis of TRH in the PVN also occurs at post-translational level through coordinated changes in proTRH processing, by the action of the prohormone convertase (PC1/3 and PC2) processing enzymes. Such regulation, which represents a novel aspect in the regulation of the neuropeptide biosynthesis, ultimately would lead to a more effective processing of prohormones into mature peptides.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
