Abstract
MicroRNAs (miRs) are evolutionarily conserved small noncoding RNAs (∼22 nucleotides) and are involved in most biological events through an RNA interference (RNAi) mechanism. Recently, we discovered a novel action of miRs to biophysically modulate the function of bound proteins. miR1, the most predominant miR in the heart, directly binds to the inward rectifier potassium channel Kir2.1 and biophysically represses the IK1 current. However, the relationship between miR's biophysical and RNAi mechanisms has not been studied.
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