Abstract
Summary Both inhalation and IT exposure provide estimates of the biopersistence of soluble fibres of similar magnitude. Inhalation systematically shows the faster clearance of longer fibres (L>20μm). For the one less soluble fibre evaluated in this study (RCF 1a), a large difference was observed between inhalation and IT exposure although as mentioned above this may be due to possible agglomeration in the bronchi following IT exposure. The results from both inhalation and IT studies were reproducible. Both methods require extensive controls to be valid. Inhalation exposure requires the aerosol to be rat respirable while IT requires confirmation of no agglomeration of fibres in the fibre suspensions used for injection and in the bronchi of the lungs following injection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
