The biology and chemistry of high-valent iron–oxo and iron–nitrido complexes

Abstract

Selective functionalization of unactivated C-H bonds and ammonia production are extremely important industrial processes. A range of metalloenyzmes achieve these challenging tasks in biology by activating dioxygen and dinitrogen using cheap and abundant transition metals, such as iron, copper and manganese. High-valent iron-oxo and -nitrido complexes act as active intermediates in many of these processes. The generation of well-described model compounds can provide vital insights into the mechanism of such enzymatic reactions. Advances in the chemistry of model high-valent iron-oxo and -nitrido systems can be related to our understanding of the biological systems.