The biology and action of colony stimulating factor-1

Abstract

Three growth factors are known to have direct effects on the survival, proliferation and differentiation of mononuclear phagocytes. These are interleukin-3 (IL-3), which regulates the proliferation and differentiation of multipotent hemopoietic cells; granulocyte-macrophage colony stimulating factor (GM-CSF), which regulates the proliferation and differentiation of neutrophilic granulocytes and mononuclear phagocytes with effects on early progenitors of the erythroid series; and colony-stimulating factor-1 (CSF-1), also known as macrophage colony stimulating factor (M-CSF) or macrophage growth factor (MGF), which selectively regulates the proliferation and differentiation of mononuclear phagocytes (reviewed in Refs. 1-3). CSF-1 is the most effective regulator of the proliferation and differentiation of mononuclear phagocytic cells, GM-CSF is less effective and IL-3 is a relatively weak mononuclear phagocyte growth factor.KeywordsPlatelet Derive Growth FactorMacrophage Colony Stimulate FactorMononuclear PhagocyteProtein Tyrosine PhosphorylationMononuclear Phagocytic CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.