The Biological Sensor for Detection of Bacterial Cells in Liquid Phase Based on Plate Acoustic Wave

Abstract

The interactions “bacterial cells – bacteriophages”, “bacterial cells – antibodies” and “bacterial cells – mini- antibodies” directly in liquid phase were experimentally investigated with a help of acoustic sensor. The acoustic sensor under study represents two-channel delay line based on the plate of Y-X lithium niobate. One channel of delay line was electrically shorted, the second channel was electrically open. The liquid container was glued on plate surface between transducers of delay line. The dependencies of the change in phase and insertion loss on concentration of bacteriophages, antibodies, and mini- antibodies were obtained for both channels of delay line.