The biological role of casomorphins (part 2): role in human pathology

Abstract

The second part of the review on casomorphins is devoted to the role of these biologically active peptides — products of phosphoprotein hydrolysis. Convincing data on the eff ect on the immune system, anti-oncogenic effect, on the motility and tone of smooth muscle fibers, the ability to control other aspects of the gastrointestinal tract activity—the transport function of the intestinal epithelium, water absorption, etc. The effect of β-casomorphins on the endocrine system, primarily on release of insulin and somatostatin. Particular attention should be paid to the question of the effect of β-casomorphins on the maternal organism during pregnancy and breastfeeding of the newborn. This is important because β-casomorphins can enter the central nervous system, being one of the factors in postpartum psychosis and depression. The study of the mechanisms of action of β-casomorphins will bring scientists closer to understanding the genesis and pathogenesis of a signifi cant spectrum of pathologies.