Abstract
Garcinia cambogia extract (GCE) comes from a tropical fruit grown in India and Southeast Asia. The active ingredient has been identified: hydroxycitric acid (HCA). It is said to block fat and suppress the appetite. It inhibits a key enzyme, citrate lyase that the body needs to make fat from carbohydrates. It suppresses appetite by increasing serotonin levels; low serotonin levels are associated with depression and emotional or reactive eating.
Highlights
Garcinia cambogia, known as Malabar tamarind, and known as Garcinia, is a plant native to Southeast Asia
Previous studies indicated that serum leptin levels and adipose tissue mass were higher in obese mice than in normal mice, but no difference was found in the serum leptiny white adipose tissue (WAT) ratio [2] (Figure 1)
The Garcinia fruit is a rich source of hydroxycitric acid (HCA), the active agent that aids in weight loss by inhibiting fat production and suppressing appetite
Summary
Known as Malabar tamarind, and known as Garcinia, is a plant native to Southeast Asia. Hydroxycitric acid (HCA), the principal acid of the fruit rind of Garcinia cambogia DSER (Hypericaceae), was shown to be a competitive inhibitor of adenosine 59-triphosphate (ATP) citrate lyase (EC 4.1.3.8), the enzyme that catalyzes the extra mitochondrial cleavage of citrate to oxaloacetate and acetyl CoA This action of HCA reduces the acetyl CoApool, limiting the availability of two-carbon units required for the biosynthesis of fatty acid and cholesterol w10, 11x. The trees are normally found growing in the riversides, forests, wastelands and have been recently cultivated for their fruits the fruits are round, oblong or oval with pointed tips and, are crowned by the four parted stalkless stigma When raw they are dark to light green in color and crimson red with a yellow tinge to dark violet or purple when fully ripe. This helps in making the rinds available throughout the year for human consumption [3]
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