Abstract
The relationship between the biological half-lives of various drugs in a whole egg and the drug contents in egg yolk and albumen, which have been presented in many papers, was examined.The regression analysis indicated a highly significant relationship (P<0.01) between the observed half-lives and the ratio of drug contents between egg yolk and albumen (Cy/a), and proposed was the following equation of the half-life (days)=1.50•Cy/a0.25. Where, Cy/a is the drug content ratio in egg yolk to in albumen at the withdrawal.The half-lives of drugs in a whole egg can be easily predicted as far as their contents in the yolk and albumen of the egg laid at the withdrawal initiation of drugs is known.
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