The Biological Fate of Sodium Prasterone Sulfate after Vaginal Administration II: Distribution after Single and Multiple Administration to Pregnant Rats.

Abstract

The distribution of sodium prasterone sulfate (PS, a common name is sodium dehydroepiandrosterone sulfate) was studied in pregnant rats after single and multiple vaginal administration of 14C-PS. The radioactivity was high in the vagina, liver and kidney, and low in the central nervous system and fat tissues after single vaginal administration. During multiple vaginal administration, plasma levels of radioactivity and the rate of urinary and fecal excretion of radioactivity were almost constant. Tissue distribution of radioactivity after multiple vaginal administration was similar to that after single vaginal administration. There were no tissues showing a pronounced retaining of the radioactivity after the multiple vaginal administration. Unchanged PS and its metabolites were transported to the cervix of uterus being an action site for PS and its some metabolites, to much higher extent after vaginal administration than after intravenous administration.