Abstract
The mechanism of isomerization of Δ 8to Δ 7cholestenol is studied in rat liver homogenates incubated with (±)[2- 3H 2]-mevalonic acid lactone. The isolated 5α-cholest-7-en-3β-ol and cholesta-5,7-dien-3β-ol were both transformed into 5α-cholesta-7,9(11)-dien-3β-ol; the latter isolated sterol was also converted into 3,8-dioxo-7,8-seco-5α-cholestan-7-oic acid. Exchange experiments with deuterium and comparison of the radioactivities of the two sterols with those of their transformation products show that the Δ 8to Δ 7isomerization does not involve an intramolecular hydride shift from the 7- to 9α- position.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
