Abstract

A satisfactory and convenient method for the biological assay of pharmaceutical preparations of chorionic and pregnant mare's serum gonadotrophin using adult dietary anoestrous rats has been described, and data are presented showing the variations in slope and RD50 during a number of years of experience in the use of the method employing the International Standards of these hormones. The findings of Heard and Winton have been fully confirmed as to the reliability and precision of the method. The suggestion made by Collip, in his early studies, that a satisfactory solution to the biological assay of anterior-pituitary-like hormones may be arrived at by the use of special diets to render the test animal acyclic has been accomplished.

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