Abstract
It is of basic and applied scientific interest to develop reliable techniques which allow the down regulation of single genes either in isolated cells or in cells of an intact organism. Such an approach should give us a more detailed insight into the particular role of single genes for growth and cell differentiation and offer us the possibility to cure cells in cases in which overproduction of a specific protein is the reason for the cellular malfunction. One promising method to decrease selectively the expression rate of either endogeneous or transgenes at the post-transcriptional level is the use of antisense RNA and DNA molecules.
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