Abstract
Studies on bimatoprost were performed with two objectives: (i) to determine whether bimatoprost possesses hair growth-stimulating properties beyond eyelash hypertrichosis and (ii) to investigate the biodisposition of bimatoprost in skin for the first time. Bimatoprost, at the dose used clinically for eyelash growth (0.03%) and given once daily for 14 days, increased pelage hair growth in C57/black 6 mice. This occurred as a much earlier onset of new hair growth in shaved mice and the time taken to achieve complete hair regrowth, according to photographic documentation and visual assessment. Bimatoprost biodisposition in the skin was determined at three concentrations: 0.01%, 0.03% and 0.06%. Dose-dependent Cmax values were obtained (3.41, 6.74, 12.3 μg/g tissue), and cutaneous bimatoprost was well maintained for 24 h following a single dose. Bimatoprost was recovered from the skin only as the intact molecule, with no detectable levels of metabolites. Thus, bimatoprost produces hypertrichosis as the intact molecule.
Highlights
Molecular studies have revealed the existence of different biological subsets of melanomas based on the patterns of alterations identified [1,2,3], some of which correlated with degree of chronic sun-induced damage and site of origin [3]
High concentrations of bimatoprost were rapidly achieved in the skin, and these remained relatively well maintained for 24 hr at about 1 lg/g tissue
The effects of bimatoprost on mouse pelage hair growth were investigated at the same dose as that employed for treating eyelashes [3,4]
Summary
Molecular studies have revealed the existence of different biological subsets of melanomas based on the patterns of alterations identified [1,2,3], some of which correlated with degree of chronic sun-induced damage and site of origin [3]. Because bimatoprost effects on other hair types have not been reported, we conducted studies on mouse pelage skin [6,7]. The cutaneous biodisposition of bimatoprost was investigated because the presence of substantially intact bimatoprost would be indicative of prostamide receptor involvement [8,9,10,11,12,13]. Substantial levels of intact bimatoprost would indicate prostamide receptor mediation [8,9,10,11,12,13].
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