Abstract
The long-term stability of the glass-ionomer cement, Ketac-0, within the bone environment has been investigated in a series of in-vivo tests conducted on the primate, the baboon Papio ursinus. A standard bulk testing procedure is described and the physiological adjustment and accommodation of the bone to the presence of this bioactive material has also been investigated. Macroscopic and microscopic evidence of the bioactive qualities of Ketac-0 are presented. It was found that the glass-Ionomer cement was non-toxic in bulk. Normal haemopoetic and osteoblastic activity took place on the cement surface, and this explains the total absence of a fibrous tissue envelopment. Long-term studies of the durability of the material under clinical condition of the functional stress situation are indicated from the results obtained to date.
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