The Biochemistry of Drug Metabolism – An Introduction

Abstract

AbstractThis paper reviews the general principles and concepts underlying Drug and Xenobiotic Metabolism. Its five Chapters deal with:1.1.Drugs and Xenobiotics,1.2.What are Drug Disposition and Metabolism?,1.3.Where does Drug Metabolism Occur?,1.4.Consequences of Drug Metabolism ‐‐ An Overview, and1.5.Drug Metabolism and Drug Discovery. This review is the first of seven Parts which will be published at intervals. The subsequent Parts will cover:2.Redox Reactions and Their Enzymes,3.Reactions of Hydrolysis and Their Enzymes,4.Conjugation Reactions and Their Enzymes,5.Metabolism and Bioactivity,6.Inter‐Individual Factors Affecting Drug Metabolism, and7.Intra‐Individual Factors Affecting Drug Metabolism.