The Biochemical Fundamental Biomarkers of The Status of Health Against Cancer and Cardiovascular Diseases: Presence of Cortisol and Melatonin Circadian Rhythms, Normal Blood Levels of Fatty Acid Amide Hydrolase (FAAH) and Transforming Growth Factor-Beta (TGF-Beta), and Normal Values of Lymphocyte-to-Monocyte Ratio (LMR) and Atrial Natriuretic Peptide (ANP)-to-Endothelin-1 (Et-1) Ratio

Paolo Lissoni,Rosa Cusmai,Giuseppe Fede,Fernando Brivio,Nicoletta Merli,Giusy Messina,Arianna Lissoni,Franco Rovelli

doi:10.29245/2578-3009/2019/3.1169

Abstract

The future of laboratory analyses would require the identification of clinical parameters involving the main integrative biological functions including neuroendocrine, immune and cardiovascular systems, and capable of predicting the evidence of metabolic alterations and the possible occurrence of systemic diseases

Highlights

Open AccessThe Biochemical Fundamental Biomarkers of The Status of Health Against Cancer and Cardiovascular Diseases: Presence of Cortisol and Melatonin Circadian Rhythms, Normal Blood Levels of Fatty Acid Amide Hydrolase (FAAH) and Transforming Growth Factor-Beta (TGFBeta), and Normal Values of Lymphocyte-to-Monocyte Ratio (LMR) and Atrial Natriuretic Peptide (ANP)-to-Endothelin-1 (Et-1) Ratio
Most laboratory analyses are performed to demonstrate possible already present metabolic alterations, such as the evidence of abnormally high values of glucose or cholesterol to establish the diagnosis of dyabetes of hypercholesterolemia
According to the clinical data available up to now, the status of health may be identified by the following five major biomarkers, consisting of normal circadian rhythm of cortisol and the pineal hormone melatonin, normal blood concentrations of fatty acid amide hydrolase (FAAH), whose increase is associated with an endocannabinoid system deficiency, normal lymphocyte-to-monocyte ratio (LMR) values, normal blood levels of TGF-beta, the main immunosuppressive anti-inflammatory endogenous molecule, and normal values of Atrial Natriuretic Peptide (ANP)-to-ET-1 ratio

Summary

Open Access

The Biochemical Fundamental Biomarkers of The Status of Health Against Cancer and Cardiovascular Diseases: Presence of Cortisol and Melatonin Circadian Rhythms, Normal Blood Levels of Fatty Acid Amide Hydrolase (FAAH) and Transforming Growth Factor-Beta (TGFBeta), and Normal Values of Lymphocyte-to-Monocyte Ratio (LMR) and Atrial Natriuretic Peptide (ANP)-to-Endothelin-1 (Et-1) Ratio. Paolo Lissoni*, Giusy Messina, Franco Rovelli, Nicoletta Merli, Rosa Cusmai, Fernando Brivio, Arianna Lissoni, Giuseppe Di Fede

Introduction

The Clinical Importance Of Cortisol And Melatonin Circadian Rhythms

Endocannabinoid System

Conclusions