Abstract
Background: Metabolic processes directly affect the bone skeleton in the human body; especially during pregnancy in females. A bone profile obtained from a blood test can reveal the changes on it. Objectives: The present study aims to estimate the changes that occur in some bone components during pregnancy and whether these changes are physiological or pathological. Patients and methods: Blood samples were collected from 126 females who attend to Al-Hadbaa primary health care center and Al-Khansaa Hospital in Mosul city during the period from January to April 2008. These females classified into two main groups; Group-1 consists of 87 normal pregnant females which are subdivided to 3 subgroups according to their gestational age. Group-2 consists of 39 non-pregnant healthy females (control group). The biochemical parameters measured were: serum calcium, serum albumin, serum inorganic phosphorus (iP), serum alkaline phosphatase (ALP), and corrected serum calcium, and the measured data for these parameters were analyzed using different statistical methods. Results: The total serum calcium, inorganic phosphorus and serum albumin decreased in pregnant female compared to the control group, while alkaline phosphatase activity was elevated in pregnant females compared to the non-pregnant females. Conclusion: The increasing in ALP during pregnancy is accompanied by decreasing serum calcium in the 2nd trimester and decreasing in iP in the 3rd trimester that could be a pathological changes related to the bone.
Highlights
Bone remodeling is mainly a local process carried out in small area by populations of cells called bone-remodeling cells
In the present study serum calcium was tend to decrease throughout pregnancy, and the difference was just significant compared to the control group, especially in the 2nd trimester compared to the control group
The conclusion of this study was similar to a study was done in the west of Iran, in which (26.4 %) of pregnant females found to be hypocalcaemic[24], other report found that maternal serum calcium does not vary with increase in the gestational age, and that there is an increase in serum calcium in pregnant females compared to the non-pregnant controls but this report was done in a developed country[25]
Summary
Bone remodeling is mainly a local process carried out in small area by populations of cells called bone-remodeling cells. Patients and methods: Blood samples were collected from 126 females who attend to Al-Hadbaa primary health care center and Al-Khansaa Hospital in Mosul city during the period from January to April 2008. These females classified into two main groups; Group-1 consists of 87 normal pregnant females which are subdivided to 3 subgroups according to their gestational age. Results: The total serum calcium, inorganic phosphorus and serum albumin decreased in pregnant female compared to the control group, while alkaline phosphatase activity was elevated in pregnant females compared to the non-pregnant females. Conclusion: The increasing in ALP during pregnancy is accompanied by decreasing serum calcium in the 2nd trimester and decreasing in iP in the 3rd trimester that could be a pathological changes related to the bone
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
