Abstract
Tropinone reductases (TRs) are short-chain dehydrogenases/reductases (SDRs) involved in tropane alkaloid biosynthesis. TRs reduce tropinone stereospecifically either to tropine (3a-tropanol), precursor of classical tropane alkaloids like hyoscyamine and scopolamine, or to pseudotropine (3b-tropanol), precursor of nortropane alkaloids e.g. calystegines. TRs were cloned and expressed from several tropane and nortropane alkaloid containing Solanaceae. In addition, one tropane alkaloid forming species of the Brassicaceae, Cochlearia officinalis, contains a special tropinone reductase (CoTR), which reduces tropinone to pseudotropine and tropine in vitro.
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