Abstract
Postmenopausal women are known to have elevated bioactivity of FSH and an increased ratio of bioactive FSH to immunoreactive FSH (B: I). We hypothesized that an elevated FSH B: I ratio would be more reflective of decreased ovarian reserve than immunoreactive FSH (I-FSH) alone. To test this hypothesis, we compared FSH B: I ratios and Mullerian Inhibiting Substance (MIS) in premenopausal women with normal, borderline, or elevated I-FSH and in normal postmenopausal (PM) controls.
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