Abstract
The binding of Ca 2+ to micelles of glycine and taurine bile acid conjugates was studied using a Ca 2+-specific electrode. An investigation of the effect of buffer concentration, pH, added electrolyte and lecithin was also carried out. The observed results indicate that the binding of Ca 2+ to bile salt micelles is dependent on both the number of hydroxyl groups on the steroid nucleus as well as on the nature of the head conjugating group, viz. glycine or taurine. It is speculated that the binding of Ca 2+ to bile salt micelles may act as one of the mechanisms to lower Ca 2+ activity in bile and thus reduce its tendency to precipitate as insoluble calcium salts and further growth into gallstones.
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