Abstract
Possible roles—physiological or pathological—for the adrenal steroids 18-OH-deoxycorticosterone (18-0H-D0C) and 18-OH-corticosterone (18-OH-B) are of wide current interest. Although no direct proof of such roles for these steroids has been established, they have been implicated in inappropriate salt retention and in some forms of hypertension. The initial step in the action of all steroid hormones studied to date appears to be the binding of the steroid to a cytoplasmic receptor in target tissue. This study examines the possibility that these 18-OH-steroids may act by binding to mineralocorticoid (Type I) or glucocorticoid (Types II and III) receptors in kidneys of adrenalectomized rats. Competitive binding assays have been used to estimate the affinity of the 18-OH-steroids relative to either aldosterone (Type I) or corticosterone (Types II and III) for the three classes of receptors. Previously determined Kdiss values of aldosterone or corticosterone are used to calculate Kdiss values of the 18-OH-stero...
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