Abstract
Using gas chromatography, the qualitative composition and the quantitative content of bile acids in the lipophilic complexes of animal bile was studied. As a result of the studies, 6 steroids were identified in the lipophilic complexes of bile, 5 of which are bile acids. It was defined that cholic and deoxycholic acid predominate in all the studied objects, while their amount depends on the used raw materials.
Highlights
Due to the intensive development and improvement of chromatographic research methods, it became possible the detail study of individual bile acids metabolism in animals and humans, poison updating in the general chain of steroid compounds conversion, further deepen understanding of the physiological action mechanisms in the body of a number of bile acids that differ in their physico-chemical properties and structure [1, 2].According to the chemical composition, bile acids are derivatives of cholanic acid and differ only in the presence of one, two or three OH-groups in different positions in the cyclic part of the molecule, mono, di- and trihydroxycholanic acids are distinguished
The results of the study of the steroid composition of animal bile and lipophilic complexes (LC) bile are shown in Tables 1-2 and Fig. 1
The content of bile acids in the BSs is 1.36 times higher than in the BBt and cholesterol is 1.49 times higher, which indicates the prospects of using BSs to produce bile acids
Summary
Due to the intensive development and improvement of chromatographic research methods, it became possible the detail study of individual bile acids metabolism in animals and humans, poison updating in the general chain of steroid compounds conversion, further deepen understanding of the physiological action mechanisms in the body of a number of bile acids that differ in their physico-chemical properties and structure [1, 2].According to the chemical composition, bile acids are derivatives of cholanic acid and differ only in the presence of one, two or three OH-groups in different positions in the cyclic part of the molecule, mono -, di- and trihydroxycholanic acids are distinguished. Physiological activity in the digestive tract is associated not with the bile acids themselves, which have low solubility in water and low surface activity, but with their conjugates and sodium and potassium salts, which are anionic detergents [10]. They promote the absorption of fats, affect intestinal peristalsis, activate enzyme systems, exhibit antiseptic properties, support and stabilize bile lipid substances, especially cholesterol, in a colloidal solution [1]
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