Abstract
A new anion—exchange resin bearing imidazolium pendant groups on a polystyrene copolymer skeleton was synthesized. This resin is a white odorless powder and the bile acid binding activities in vitro were much more potent than those of cholestyramine. The ion- exchange equilibrium coefficient K phosphoric acid ion − bile acid ion − was 271, compared to that of cholestyramine which was 32. The hypocholesterolemic activity of this resin in cholesterol-fed rabbits proved to be 1.5-fold more potent than that of cholestyramine. Thus, the effective reduction of plasma cholesterol may be achieved with significantly lower doses of this resin.
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