Abstract
The paper analyses the epidemic pattern of respiratory syncytial virus (RSV) outbreaks in children in Croatia. Over a period of 11 consecutive winter seasons (1994–2005) 3,435 inpatients from Zagreb County aged from infancy to 10 years who were hospitalised with acute respiratory tract infections were tested for RSV-infection. RSV was identified in nasopharyngeal secretions of patients by virus isolation in cell culture and by detection of viral antigen with monoclonal antibodies.In the Zagreb area, RSV outbreaks were proven to vary in a two-year cycle, which was repeated every 23–25 months. This biennial cycle comprised one larger and one smaller season. Climate factors correlated significantly with the number of RSV cases identified only in the large seasons, which suggests that the biennial cycle is likely to continue regardless of meteorological conditions. Knowledge of this biennial pattern should be useful in predicting the onset of RSV outbreaks in Croatia, and would facilitate planning for the prevention and control of RSV infections in the region.
Highlights
1980s, respiratory syncytial virus (RSV) was determined to be the agent of 20–34% of inpatient acute respiratory tract infections (ARTI) [1,2]
Our study of RSV-genotypes circulating in Zagreb and Vienna from 1987–1994 showed that they were similar to the pattern of expression of these genotypes globally [3]
RSV infections occur in winter and in the early spring [1,4]
Summary
Gordana Mlinaric-Galinovic*1, Robert C Welliver, Tatjana Vilibic-Cavlek, Suncanica Ljubin-Sternak, Vladimir Drazenovic, Ivana Galinovic and Vlatka Tomic.
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