Abstract
Background Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated b-amyloid-precursor-protein (APPswe), P310L-Tau (TauP301L) and physiological levels of M146Vpresenilin-1 (PS1M146V) display extracellular amyloid-beta peptides (Abeta) deposits and Tau tangles at late ages. These mice also show an early, age-dependent and hippocampus specific accumulation of intra-neuronal APPrelated materiel, which was firstly reported to correspond to Abeta. However, more recent work has disputed the presence of intra-neuronal Abeta and questioned its role in synaptic pathology and behavior.
Highlights
Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated b-amyloid-precursor-protein (APPswe), P310L-Tau (TauP301L) and physiological levels of M146Vpresenilin-1 (PS1M146V) display extracellular amyloid-beta peptides (Abeta) deposits and Tau tangles at late ages. These mice show an early, age-dependent and hippocampus specific accumulation of intra-neuronal APPrelated materiel, which was firstly reported to correspond to Abeta
More recent work has disputed the presence of intra-neuronal Abeta and questioned its role in synaptic pathology and behavior
We show that C99 accumulation is not linked to a defective gamma-secretase processing
Summary
Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated b-amyloid-precursor-protein (APPswe), P310L-Tau (TauP301L) and physiological levels of M146Vpresenilin-1 (PS1M146V) display extracellular amyloid-beta peptides (Abeta) deposits and Tau tangles at late ages. The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse From Molecular Neurodegeneration: Basic biology and disease pathways Cannes, France. Background Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated b-amyloid-precursor-protein (APPswe), P310L-Tau (TauP301L) and physiological levels of M146Vpresenilin-1 (PS1M146V) display extracellular amyloid-beta peptides (Abeta) deposits and Tau tangles at late ages.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
