The best coagulation marker for prediction of COVID-19 pneumonia progression

Abstract

Coagulation marker wich&nbsp;can really reflect the COVID-19 pneumonia progression is still unknown. The aim was to estimate the diagnostic and prognostic role of D-dimer in hospitalized patients(pts) with confirmed COVID-19 pneumonia as marker of progression. <b>Materials and methods:</b> The main group was 53 pts (age – 59(52;65), men – 22(41,5 %)) with COVID-19 pneumonia, divided into 3 groups (G): G1 – 36 pts with moderate COVID-19 pneumonia, G2 – 12 pts with severe COVID-19 pneumonia, G3 – 5 pts with critical COVID-19 pneumonia. D-dimer was performed at admission before treatment starting. <b>Results:</b> Individual analysis showed that 28 pts from G2 and G3 had progression of COVID-19 pneumonia in dynamic,&nbsp;which was manifested with increased respiratory failure. The ROC-analysis showed that the level of D-dimer can really reflects the severity of COVID-19 pneumonia and predict the prognosis of the disease (Fig.1) <b>Conclusions:</b> 1) Increasing of D-dimer on level&nbsp;199 ng/ml at admission not only reflects the severe or critical course of in hospitalized patients with COVID-19, but also predicts the progression of disease.