THE BENEFITS OF AEROBIC TRAINING ON LIPID METABOLISM OF YOUNG AND ELDERLY FEMALE OBESE RATS TREATED WITH MONOSODIUM GLUTAMATE (MSG)

Abstract

Several studies attest the benefits of physical activity on various parameters in life of men and animals. We accomplished in our laboratory previous studies in rats treated with MSG (that remained obese in adult life), confirming the positive effects of aerobic exercise. In the current study, we evaluated the effects of exercise protocol (swimming, 90 min/day, 5 days/week, 30 to 90 day of life) in female rats, young and elderly, with the aim of verifying the influence of age in exercise response. The Wistar rats were divided in 8 groups: CSY-Control Sedentary Young; CEY-Control Exercised Young; OSY-Obese Sedentary Young; OEY-Obese Exercised Young; CSE-Control Sedentary Elderly; CEE-Control Exercised Elderly; OSE-Obese Sedentary Elderly and OEE-Obese Exercised Elderly. We evaluated: the relative weight (g/100g b.w.) of the retroperitoneal (RET) and parametrial (PAR) white adipose tissue depots, plasma (mg/dl) total lipids (TL), cholesterol (C), HDL-cholesterol (HDL-C). RET and PAR relative weights were increased in sedentary groups CSY (0.65 ± 0.1; 1.53 ± 0.2); OSY (1.40 ± 0.1; 3.96 ± 0.3); CSE (0.81 ± 0.07; 2.03 ± 0.29) and OSE (2.17 ± 0.22; 5.44 ± 0.32). The exercise decreased the weights of these tissues significantly only in the obese rats (OEY: 0.79 ± 0.1; 2.24 ± 0.2 and OEE: 1.69 ± 0.21; 4.52 ± 0.33). Similar results were achieved in Plasma TL and C and significant decrease were observed in these parameters in obese exercised animals when compared to sedentary ones in both groups: Total Lipids (OEY: 154.5 ± 7.9; OSY: 254.1 ± 19.6 and OEE: 145.1 ± 11.9; OSE: 205.7 ± 18.9) and Cholesterol (OEY: 93.5 ± 7.3; OSY: 127.6 ± 8.6 and OEE: 80.6 ± 5.9; OSE: 108.6 ± 8.6). In HDL-C significant changes were not observed in the animals studied. These results suggest that aerobic training promote benefits in lipid metabolism of the obese rats treated with monosodium glutamate attenuating the obesity in both young and elderly rats. Supported by CAPES