The Beneficial Effects of Collagen Tripeptide on Deep Wrinkling and Skin Moisturization: A Randomized Controlled Trial

Abstract

Dietary collagen is now widely considered as an effective supplement to improve skin appearance by improving elasticity and moisturization. However, because the mechanism of absorption in the body is not clear, collagen-peptides are developed as an active ingredient in the health care market for skin. The aim of this study was to assess whether oral administration of collagen tripeptide (CTP) improves wrinkling and skin hydration. This was a double-blind, randomized, placebo-controlled trial. We evaluated skin changes after oral intake of CTP in participants 40-55 years of age who had wrinkles around their eyes and dry skin. They received either a test product with CTP (n=35) or a placebo (n=38) for 12 weeks. At weeks 0, 6, and 12, water contents were measured on the right and left cheek with a Corneometer®, and eye wrinkles were evaluated on both sides around the eyes by Primos CR. In the CTP group, roughness parameters were significantly reduced around the eyes. Additionally, the difference between the CTP and placebo groups was statistically significant. The capacitance for moisture significantly increased after oral supplementation of CTP. Interestingly, the capacitance was significant between the CTP and placebo groups after excluding participants who did not use sunscreen, used colored makeup at least five times a week, or slept less than 5 hours a day. Additionally, more 45 years of age women were significantly increased skin moisture compared to placebo group. Administration of CTP was well-tolerated, and no notable adverse effects were reported in either group. Oral supplementation of CTP is safe and helpful to the skin appearance, improving wrinkle formation and skin hydration.