Abstract
Objective: The objective of this study was to evaluate the beneficial effect of topical applications of 20% sunflower seed oil (SSO) in decreasing the transepidermal water loss (TEWL) and scoring of atopic dermatitis (SCORAD) index value in mild atopic dermatitis (AD) pediatric patients in Bandung, Indonesia.
 Methods: This was a randomized study involving 20 children with mild AD (SCORAD<25) in Bandung, Indonesia. They were divided into 2 groups: the experimental group treated with 20% SSO cream and the control group treated with a common moisturizing cream for four weeks. The TEWL score including SCORAD index was evaluated at baseline, week 1, week 2, and week 4.
 Results: A total of 20 participants completed the study. In the first week, the control group had TEWL score decrement by 36.62% while the experimental group by 28.89% (p=0.88). In the fourth week, the TEWL decrements of the experimental and control group were by 56.94% and 52.50%, respectively (p=0.20), and this was followed by an improvement of SCORAD index in both treatment groups.
 Conclusion: The 20% SSO cream has a beneficial effect in decreasing the TEWL score and improving SCORAD indices. Therefore, it can be considered as an alternative treatment for mild AD among children.
Highlights
Atopic dermatitis (AD) is an inflammatory skin condition characterized by intense pruritus in a waxing and waning course [1]
The transepidermal water loss (TEWL) scores in both treatment groups were measured on the right arm, left arm, right leg, and left leg
There was a reduction of TEWL scores in both treatment groups
Summary
Atopic dermatitis (AD) is an inflammatory skin condition characterized by intense pruritus in a waxing and waning course [1]. It affects 10-20% children and 1-3% adults worldwide, with a female to male ratio of 1.3:1.1 [1]. Scoring of atopic dermatitis (SCORAD) is a clinical tool used to assess the extent and severity of AD, which can be used before and after treatment to determine its effectiveness. It measures the of the extent of skin lesions, the intensity of the disease, and subjective complaints [6]
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