The behavioral performance tests of Mucuna pruriens gold nanoparticles in the 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine treated mouse model of Parkinsonism

Abstract

ObjectiveThe present investigation is aimed to carry out the behavioural changes of the Mucuna pruriens extract (MPE) and Mucuna pruriens Goldnanoparticles (MPGNPs) against MPTP-induced neurotoxicity. MethodsMPGNPs prepared from the methanolic extract of Mucuna pruriens seeds using Chloroauricchloride (HAuCl4). The seed powder has been found to show the anti-parkinsonian effects. Mice were induced with 10 mg/kg of MPTP, four injections i.p., at 1 h intervals within 24 h. MPE was administered at the dose 200 mg/kg (i.p) and MPGNPs was administered at different doses of 500 μg/kg, 5, 10 and 20 mg/kg (i.p) in different groups once a day for seven days and the dose on the first day was given 30 min prior to first MPTP injection. ResultsThe behavioural changes were studied using the rotarod test, hang test and narrow beam test. MPE and MPGNPs significantly (P < 0.05) improved the behavioural activities. ConclusionsMPGNPs possesses significant behavioural activity than MPE against MPTP induced neurotoxicity.