Abstract
Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic systems in the central nervous system. In migraine it is supposed to occur hyperactivation of central dopaminergic pathways. We verified the hypothesis of improved migraine in patients who manifest PD. We evaluated 109 patients with PD over 40 years (57 men and 52 women) about the presence throughout the life of migraine, as well as the possibility of improvement in migraine after the onset of motor symptoms of PD. This group was compared to a control group of 152 people (41 men and 152 women) without PD regarding the presence of migraine and its improvement. Twenty-one patients manifested migraine in the group with PD (16 women and 5 men) in which 13 reported improvement in migraine after the onset of symptoms of PD. Among the controls, 37 interviewed had migraine history (32 women and 5 men) among which 20 showed improvement. There was no significant difference when comparing the two groups (χ21:0,05=0.337; P<0.382). We were unable to relate the improvement of migraine with the emergence of PD motor signs, despite the degeneration of dopaminergic pathways of the central nervous system.
Highlights
Parkinson’s disease is the second most common degenerative disease of the central nervous system (CNS) second only to Alzheimer’s disease.[3]
We evaluated 109 patients r with Parkinson’s disease (PD) over 40 years (57 men and 52 women) e about the presence throughout the life of migraine, as well as the possibility of improvem ment in migraine after the onset of motor m symptoms of PD
This group was compared to a control group of 152 people (41 men and 152 o women) without PD regarding the presence of c migraine and its improvement
Summary
33 25 58 dementia, the use of prophylactic medication for migraine up to one year before the survey and patients of the headache clinic at HUAP. The study was approved by the Antônio Pedro University Hospital Ethics
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