Abstract
Results 44 peanut allergic children (median age 5 years) reacted to peanut on DBPCPC with clinical symptoms than ranged from oral allergy syndrome to anaphylaxis. 61% of patients reacted to 0.1g of peanut protein. The mean %CD63+ basophil at 10 and 100 ng/ml of PE was independently associated with severity (p=0.012) whilst CD-sens (1/EC50x100) was independently associated with threshold (p=0.039) of allergic reactions to peanut. Severity and threshold parameters were correlated both at the clinical (Rs=-0.38; p=0.013) and at the basophil level (Rs=0.65; p<0.001).
Highlights
Peanut allergic patients may react to small amounts of the allergen with symptoms that can be life-threatening
Basophil reactivity and sensitivity are associated with severity and threshold of allergic reactions to peanut on DBPCPC
44 peanut allergic children reacted to peanut on DBPCPC with clinical symptoms than ranged from oral allergy syndrome to anaphylaxis. 61% of patients reacted to 0.1g of peanut protein
Summary
Peanut allergic patients may react to small amounts of the allergen with symptoms that can be life-threatening. The management of peanut allergy (PA) relies on allergen avoidance and adrenaline auto-injector for rescue treatment in cases at risk of anaphylaxis. Biomarkers of severity and threshold could improve the management of PA
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