The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression.

Zeyu Wang,Quan Cheng,Mingyu Zhang,Ziyu Dai,Gelei Xiao,Songshan Feng,Zhixiong Liu,Hecun Zou,Xing Wang

doi:10.3389/fimmu.2020.01757

Abstract

The pentraxin is a superfamily of proteins with the same domain known as the pentraxin domain at C-terminal. This family has two subgroups, namely; short pentraxins (C-reactive protein and serum amyloid P component) and long pentraxins (neuronal pentraxin 1, neuronal pentraxin 2, neuronal pentraxin receptor, pentraxin 3 and pentraxin 4). Each group shares a similar structure with the pentameric complexes arranged in a discoid shape. Previous studies revealed the functions of different pentraxin family members. Most of them are associated with human innate immunity. Inflammation has commonly been associated with tumor progression, implying that the pentraxin family might also participate in tumor progression. Therefore, we reviewed the basic characteristics and functions of the pentraxin family and their role in tumor progression.

Highlights

The pentraxin family is a superfamily of protein that share the same domain and are made from monomers arranged in pentameric structures with a discoid shape [1]
pentraxin 3 (PTX3) interacts with the PI3K/AKT/mTOR signaling pathway to induce tumor cell proliferation, apoptosis and metastasis in lung cancer [9], head and neck squamous cell carcinoma [74] and breast cancer [117]
We revealed that low NPTX1 expression improved the survival outcomes in patients with adrenocortical carcinoma (ACC), urothelial bladder carcinoma (BCLA), kidney renal papillary cell carcinoma (KIRP), stomach adenocarcinoma (STAD) and uveal melanoma (UVM), (Figures 4D–H)

Summary

Introduction

The pentraxin family is a superfamily of protein that share the same domain and are made from monomers arranged in pentameric structures with a discoid shape [1]. The CRP arrest cellcycle at the sub G1 phase by negatively regulating the PI3K/AKT/mTOR signaling pathway in myeloid leukemia [25] and tongue squamous cell carcinoma [26] promoting tumor progression. It has been reported that interaction between CRP and Fcγ receptor I facilitate tumor cell metastasis in breast cancer [23].

Results

Conclusion