Abstract

Lung cancer in low-and middle-income countries is the leading and the second leading cause of cancer deaths in males and females, respectively. This, in part, is due to late presentation of patients in health facilities and late diagnosis, thereby compromising the effectiveness of treatment and resulting in poor treatment outcomes. Investigating patients’ late presentation to health facilities and late diagnosis, as barriers to achieving good treatment outcomes, is an important step towards improving the existing pathways of care. Therefore, the aim of this paper is to critically review the published and unpublished literature, including government reports on lung cancer care, with regards to the barriers to patient access, referral, diagnosis and treatment in low-and middle-income countries. The emphasis is on access point and the primary care continuum. This review has been packaged into themes in order to efficiently inform researchers and cancer health professionals, on the existing gaps necessary for developing appropriate intervention strategies and policy guidelines. This review has revealed that the timeous and correct diagnosis of lung cancer enables lung specialists to engage on options for improved patient care. Currently, there are variations in lung cancer management in low-and middle-income countries. Many of the factors impacting on health care outcomes are a function of patient circumstances and/or understanding, leading to delays in presentation to health facilities. Factors pertaining to individual patient circumstances are further compounded by inefficiencies within the health care system. Therefore, limited health system capacities and competing health priorities in these settings require action.

Highlights

  • Cancer morbidity and mortality is increasingly becoming a major public health problem and it is the second leading cause of death worldwide [1]

  • While the overall incidence of cancer is lower in lowand middle-income countries (LMICs) compared with high-income countries (HICs), total cancer-related mortality is significantly higher in LMICs [2]

  • The findings presented in this paper can be summarized through the following illustrative diagram (Figure 1): we present the results in thematic areas; the main themes being: ’Patient Interval‚, ’Cultural and Societal Differences‚, and ’Health Systems Context‚ with their respective subthemes/ barriers to early access to lung cancer care

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Summary

Introduction

Cancer morbidity and mortality is increasingly becoming a major public health problem and it is the second leading cause of death worldwide [1]. The World Health Organisation's (WHO) projections indicate that global annual estimates will increase to 29.5 million new cancer diagnoses and 16.5 million cancer-related deaths, by the year 2040 [2, 6, 7], unless drastic interventions are implemented. In both sexes combined, lung cancer is the most commonly diagnosed cancer (11.6% of the total cases) and the leading cause of cancer death (18.4% of the total cancer deaths), closely followed by female breast cancer (11.6%), prostate cancer (7.1%), and colorectal cancer (6.1%) [6]. In Africa, lung cancer is the fourth most common cancer among men with approximately 39,300 and 37,700 new lung cancer cases and annual mortality, respectively [11, 12]

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