Abstract
1. 1. The growth of gram-positive and gram-negative bacterial cultures were not significantly inhibited by 500 μg./ml. of C 4, C 6, C 16, and C 18 saturated fatty acids. Both gram-positive and gram-negative organisms were inhibited by the C 8 and C 10 saturated fatty acids. Only the gram-positive organisms tested were significantly inhibited by the C 12 acid. The C 14 acid caused growth inhibition at low concentrations in two of the microorganisms tested. 2. 2. With each increase of 2 carbon atoms from C 8 through C 12, the bacteriostatic effect increased an average of 3.5 times. A correlation is described between the increase in bacteriostatic effect and decrease in water solubility as the number of carbon atoms is increased. 3. 3. Increasing susceptibility to bacteriostasis by the C 10 acid among the microorganisms tested was found to be correlated with an increasing number of the members of the saturated fatty acid series, C 8, C 12, C 14, which cause bacteriostasis.
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