Abstract
Silver nanoparticles have mainly been studied for their antimicrobial potential against bacteria, but have also proven to be active against several types of viruses, even against pebrine as well. Methods: Petri dishes and transmission electronic microscope were applied to observe silver nanoparticles against bacteria strains and nuclear polyhedral viruses (NPV) and cytoplasmic polyhedral viruses (CPV). For biological test, 108 CFU/mL NPV with strong pathogenicity, and the NPV samples treated with 1:100 ratio of “Sumerian Silver” for 8 hrs were sprayed on the mulberry leaves, respectively, for silkworm rearing. Conclusion: Silver nanoparticle solution showed a strong bactericidal effect against both G+ and G﹣bacterial pathogenic strains from Bombyx mori and mulberry. Under transmission electronic microscope (TEM), Bacillus sp. Samples showed light particles in the cells when treated with silver nanoparticles, in contrast, untreated samples showed homogeneity contents. Further, NPV particles showed no significant differences between treated and untreated samples, but CPV showed strong effects that almost all CPV were collapsed. For biological test, “Sumerian Silver” treated NPV showed no diseased silkworm but nearly all silkworms were dead with no treatment. It seems like that silver nanoparticles were proved to be more effective against CPV than that of NPV. The significant differences between two antivirus or virucidal mechanism should be greatly aroused the scientific interest.
Highlights
Nanotechnology was rapidly developed after scanning tunneling microscope
Streptococcus aureus, and broad biotic-control agents of Shamin bacterium were kindly provided by Lab of Silkworm Disease in Department of Sericulture Science, College of Animal Science, South China Agricultural University (SCAU); Aecidium mori (Barclay), a fungal disease of mulberry leaves was isolated and purified by Lab of Insect Physiology and Biochemistry from diseased mulberry leaves in Hainan province of South China
Viral pathogens of silkworm: Nuclear polyhedral virus (NPV) and cytoplasmic polyhedral virus (CPV) were provided by Lab of Silkworm Disease in SCAU
Summary
Nanotechnology was rapidly developed after scanning tunneling microscope. Up to now, there are 1317 kinds of nanoscale products all over the world. The rapid development of nanotechnology made a point of every country in the world It was one of six research pivots of National Major Developments in Scientific Research Programs of China. Particle size and size distribution are the most important characteristics of nanoparticle systems They received attention when it was shown that 10 nm silver nanoparticles were bactericidal, which were promising in light of the growing number of antibiotic resistant bacteria. Lara et al [8] suggested that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles are effective virucides as they inactivate HIV particles in a short period of time, exerting their activity at an early stage of viral replication (entry or fusion) and at postentry stages [9]. According to the characters of silver particles, the study initially focused on the bactericidal and antiviral effect on some pathogens to silkworm and mulberry
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