Abstract
Bacteria have evolved surface-exposed polymers called pili with remarkable physical properties. This highlight describes recent advances in the biophysics of type IV pilus systems. They are strong molecular motors whose velocity and force are tunable by external inputs. Coordination of multiple pili for mediating pilus-driven surface motility depends on cell shape, surface interaction, and cooperation with other motors. Rational design of surfaces can control pilus-mediated surface movement and potentially biofilm architecture.
Highlights
Bacteria have evolved surface-exposed polymers called pili with remarkable physical properties
Many bacterial species live at surfaces, and there they encounter a con ict
There is increasing evidence that force generation by T4P affects the interaction between pathogenic Neisseria and their human host cells, it is unclear what function high force generation may have in other bacterial species that inhabit different niches
Summary
Open Access Article. Published on 22 May 2013. Downloaded on 11/8/2021 4:12:06 PM. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Received 22nd February 2013 Accepted 11th April 2013 DOI: 10.1039/c3sm50546d www.rsc.org/softmatter
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