Abstract
The growth and evolution of human tissues observed in embryogenesis and neoplasia are both reduced to a cellular theoretical axio-somatic model. The unlimited expansion and phenotype change of the model, are assured by the continuous generation of new cellular mitotic phenotypes which are grafted in a sequential order. Neogeneration results from the interaction between two cells of specific origins and situations: (a) axial cells of actual germ cell origin, generators and vectors of mitotic potential, (b) mitotically exhausted somatic cells of distal phenotypes, involved in meiotic recombinations, generating potential of neodifferentiation. The potentialities of both, axis and soma, are transformed by ‘fertilization’ in effectively growing new mitotic phenotypes. Bi-potent differentiation of germ line derived cells in gametopoiesis and haematopoiesis, is the source of the axial phenotype, identified in tissues as specific acid fast ‘lymphoid’ cells and/or vectors, formed by highly condensed hyperchromatinic nuclei and/or micronuclei endowed with DNAs of centromeric and kinetochoric types, wrapped in ceramide rich photo-affinity biomembranes.
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