Abstract

BackgroundChina ranks first amongst the countries for the abuse of antibacterials. Essential antibacterials could help solve the problem. The aim of the work is to evaluate the availability, price and affordability of essential antibacterials in Hubei province, China.MethodThe standardized methodology developed by the World Health Organization and Health Action International was used to collect data on the availability and prices of 16 antibacterials in 5 cities of Hubei province, China.ResultsFirst, in total, the median availability of originator brands and lowest-priced generics for the essential antibacterials was low, 3.0% (0.0, 18.2%) and 33.3% (0.0, 87.9%) for each, respectively. Second, the median price ratio of originator brands for the antibacterials was 20.30 (4.71, 35.80), while for generics, it was 0.49 (0.07, 1.18). Third, the affordability of originator brands for the antibacterials was 28.14 (21.70, 41.90) times the daily wages of an unskilled government worker, while for generics, the affordability was 0.35 (0.04, 6.11). Finally, we found that in Hubei province, lowest-priced generics for essential antibacterials with (fairly) high availability and relatively low price included Amoxicillin/Clavulanic Acid, Ceftazidime, Metronidazole, Gentamicin Sulfate and Ceftriaxone.ConclusionThe prices of lowest-priced generics for essential antibacterials in Hubei province were reasonable, and in tertiary hospitals the availability was the highest, while in secondary and primary hospitals, it was relatively lower. Originator brands were not only extremely expensive but also difficult to obtain. Measures should be taken to improve the availability of essential antibacterials and the affordability of originator brands.

Highlights

  • China ranks first amongst the countries for the abuse of antibacterials

  • Measures should be taken to improve the availability of essential antibacterials and the affordability of originator brands

  • This study aimed to evaluate the effects of essential medicine policy on the availability of antibacterials in Hubei province and to assess the prices of originator brands (OBs) and lowest-priced generics (LPGs) for essential antibacterials

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Summary

Introduction

Essential antibacterials could help solve the problem. As more and more antibacterials are provided, overuse and misuse of them have been a serious problem. Overusing and misusing antibacterials is a key driver of bacteria resistance. When a new antibacterial is introduced into medical usage, drug resistance to it follows naturally, but it sometimes comes swiftly [7]. China had the largest consumer group of antibacterials use besides Brazil, Russia, India and South Africa [8]. In 2010, China was the second largest consumption of antibacterials with 10.0 × 10 [9] units, following India [8]. While in 2013, 92,700 t of antibacterials were consumed in China, and 48% of which were used in humans [3].

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