Abstract
Axially chiral biaryls constitute a rapidly growing class of structurally, biosynthetically, and pharmacologically intriguing natural products, among them dimeric sesquiterpenes like mastigophorene A (1),1 but also mixed, constitutionally unsymmetric biaryls like the naphthylisoquinoline alkaloids,2 e.g. ancistrocladine (2)3 and dioncophylline A (3),4 some of them disposing of axial and centrochirality (Figure 1). As broad as their structural variety is the diversity of their sometimes most promising bioactivities, like nerve growth stimulating,1 antimalarial,5 or molluscicidal6 properties. Furthermore, axially chiral biaryl reagents or ligands are of increasing value in stereoselective synthesis.7
Published Version
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