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Abstract
The kinetochore links chromosomes to spindle microtubules to drive chromosome segregation at cell division. To do so, its attachments to microtubules must be both dynamic and strong. While we know nearly all mammalian kinetochore proteins, how these give rise to dynamic yet strong microtubule attachments remains poorly understood. Here, we focus on the Astrin-SKAP complex, which localizes to bioriented kinetochores and is essential to chromosome segregation, but whose mechanical role is unclear.
Published Version
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