Abstract
BackgroundThe associations between the polymorphisms in Cytotoxic T lymphocyte-associated molecule-4 (CTLA-4) gene and Graves’ disease (GD) have been extensively investigated in Chinese population. However, the results were inconsistent. The objective of this study is to investigate the associations between the polymorphisms in CTLA-4 gene and the risk of GD by meta-analysis.MethodsWe searched Pubmed database, Medline (Ovid) database, CNKI database and Wanfang database, covering all studies until August 11, 2012. Statistical analysis was performed by using the Revman4.2 software and the Stata10.0 software.ResultsA total of 28 case–control studies concerning the most widely studied three polymorphisms [+49A/G(rs231775), -318C/T(rs5742909) and CT60(rs3087243)] for Chinese population in 21 publications were included. The results suggested that the G allele carriers (GG+GA) might have an increased risk of GD when compared with the AA homozygote carriers for the +49A/G polymorphism (GG+GA vs. AA: OR = 2.57, 95%CI = 1.87-3.52). However, as to the -318C/T polymorphism and CT60 polymorphism, the results indicated that the variant allele carriers might have decreased risks of GD when compared with the homozygote carriers (−318C/T: TT+TC vs. CC: OR = 0.78, 95%CI = 0.62-0.97; CT60: AA+AG vs. GG: OR = 0.64, 95%CI = 0.52-0.78).ConclusionsThe current meta-analysis indicated that the polymorphisms in the CLTA-4 gene might be risk factors for GD in the Chinese population. In future, more large-scale case–control studies are needed to validate these results.
Highlights
The associations between the polymorphisms in Cytotoxic T lymphocyte-associated molecule-4(CTLA-4) gene and Graves’ disease (GD) have been extensively investigated in Chinese population
The results suggested that the G allele carriers (GG+GA) might have an increased risk of GD when compared with the AA homozygote carriers for the +49A/G polymorphism (GG+GA vs. AA: odds ratio (OR) = 2.57, 95%confidence intervals (CI) = 1.87-3.52)
As to the -318C/T polymorphism and CT60 polymorphism, the results indicated that the variant allele carriers might have decreased risks of GD when compared with the homozygote carriers
Summary
(CTLA-4) gene and Graves’ disease (GD) have been extensively investigated in Chinese population. The objective of this study is to investigate the associations between the polymorphisms in CTLA-4 gene and the risk of GD by meta-analysis. Graves’ disease (GD) is a complex autoimmune thyroid disease, which is caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland, protrusion of the eyeballs, a rapid heartbeat and nervous excitability [1]. It is widely accepted that GD is caused by complex interactions between many genetic. West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. The Periodical Press of West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan 610041, China factors and environmental factors. Numerous studies have been published focusing on the topic of genetic factors of GD risk in the Chinese population. The CTLA-4 gene is one of the most extensively studied Many genes involved in the inception and evolution of GD have been identified as GD candidate genes, such as ADRB2 [3], TSHR [4], CTLA-4 [5] and IL-13 gene [6].
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