Abstract
We aimed to evaluate the relationship between selected serum sex hormones and lipid profiles in a group of women with polycystic ovary syndrome (PCOS) dividing according to four phenotypes, value of body mass index (BMI), and presence of hyperlipidemia. The study included 606 Caucasian women. Lipids and selected hormones were estimated using commercially available procedures during hospitalization in 2017. Phenotype of PCOS, BMI value, and hyperlipidemia were significant factors that influenced androgen hormone concentrations, such as total and free testosterone and androstenedione as well as the value of free androgen index (FAI). Moreover, significant changes in concentrations of dehydroepiandrosterone sulphate and sex hormone binding globulin (SHBG) were found between those groups. Higher quartiles of triglyceride concentrations increased the odds ratio of decreased concentrations of SHBG or increased values of FAI, while an adverse relation was found in case of HDL-C. The concentration of estradiol in the blood of women with PCOS was not associated with lipid profile parameters in any investigated groups. Probably, irregularities in sex hormone concentrations during PCOS is not directly associated with lipid profile parameters but could be reflective of the concentration of SHBG or the ratio of SHBG and total testosterone and their association with lipids.
Highlights
Polycystic ovary syndrome (PCOS) is a common endocrinological disorder in women of reproductive age [1,2,3]
We aimed to evaluate the relationship between selected serum sex hormones such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), free testosterone (FT), AD, dehydroepiandrosterone sulfate (DHEA-S), estradiol (17-β-E2), 17α-hydroxyprogesterone (17α-OHP), cortisol, sex hormone binding globulin (SHBG), and lipid profile parameters including CHO, LDL-C, HDL-C, and TG in a group of women with PCOS
We found significant differences in the values of body mass index (BMI) and Waist-to-hip ratio (WHR) between women with different phenotypes of PCOS, while the age of study participants was similar in those subgroups
Summary
Polycystic ovary syndrome (PCOS) is a common endocrinological disorder in women of reproductive age [1,2,3]. PCOS affects approximately 6% to 20% of women of reproductive age [4] and is characterized by clinical and/or biochemical hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphologic features [5]. IR affects approximately 65–70% of women with PCOS, and roughly 70–80% of women with PCOS are overweight or obese [8] Both IR and accompanying obesity play crucial roles in the pathogenesis of androgen excess in PCOS [9]. Abdominal obesity induces ovarian and adrenal androgen production, whereas sex hormone binding globulin (SHBG) level is decreased. It is possible that visceral obesity increases activity in the hypothalamus–pituitary–adrenal axis, which could increase the level of hormones produced by the adrenal cortex adrenal hormones [12]
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